Published: Apr 14, 2014 8:40 AM EDT

FORT MYERS, Fla. -- People get otox for a number of reasons, but new studies suggest it can significantly improve symptoms of depression.

Dr. Michael Kim says a new study published in the Journal of Psychiatric Research reports patients injected with Botox demonstrated a substantial improvement, 52%, in their depressive symptoms.

Depressive symptoms, as assessed by the MADRS scale, in the Botox treatment group decreased 47 % after six weeks, compared to 21% in the placebo group.

The study says, "frowning may affect the way people feel about themselves when they look in the mirror and the way others respond to them." Also, "facial expressions may in?uence mood by facilitating more positive social interactions with others. Frowning may in and of itself be depressogenic . Thus, reduction in frowning may be in and of itself therapeutic."