Published: Aug 16, 2012 1:15 AM EDT
Updated: Aug 16, 2012 6:31 AM EDT

ANAHEIM, Calif. (AP) - Mike Trout and Chris Iannetta homered to help the Los Angeles Angels build a big lead against Roberto Hernandez in his season debut with Cleveland, and Ervin Santana breezed to an 8-4 victory over the Indians on Wednesday night.

Santana (6-10) allowed a run and four hits in seven innings, struck out four and walked one. The only run came on a sixth-inning double by Asdrubal Cabrera. Santana, whose only other victory against the Indians was a no-hitter at Cleveland on July 27, 2001, is 2-8 in 14 career starts against the Tribe.

Jason Isringhausen gave up a three-run homer in the eighth to Shin-Soo Choo, his 14th this season, but Kevin Jepsen closed it out with a perfect ninth.

Hernandez, formally known as Fausto Carmona, was added to the Indians' 25-man roster on Tuesday after fellow right-hander Josh Tomlin was placed on the 15-day disabled list because of inflammation in his elbow.

Hernandez, beginning his seventh big league season, was arrested in January outside the U.S. consulate in the Dominican Republic while trying to renew his visa - which he finally was granted on July 21 after he was found to be three years older than his listed age. The right-hander, who turns 32 on Aug. 30, made four minor league starts while serving a three-week suspension from Major League Baseball for age and identity fraud.

Hernandez threw 91 pitches through six innings, allowing eight runs - five earned - and 10 hits with no walks or strikeouts. He is 23-49 with a 5.03 ERA in 111 starts since his breakout season of 2007, when he was 19-8 with a career-best 3.06 ERA for the Indians and was part of a formidable rotation that included CC Sabathia, Cliff Lee, Jake Westbrook and Paul Byrd.

The Angels parlayed five hits and three errors into a five-run second inning. Two of the errors were by recently acquired shortstop Brent Lillibridge, who butchered a potential double-play grounder by Vernon Wells and later made a wild throw to the plate.

Alberto Callaspo opened the scoring with an RBI single, and Wells was credited with an RBI on the misplayed grounder to Lillibridge. Maicer Izturis then reached on a bunt single after Hernandez and catcher Carlos Santana both went for the ball to the right of the plate and missed it trying to avoid a collision.

That loaded the bases for Iannetta, who hit a sacrifice fly. Trout grounded into a force play and stole second - drawing an errant throw by Carlos Santana that deflected off Lillibridge's glove and allowed Wells to score. Lillibridge made a wild throw trying to get Wells, enabling Trout to end up at third, and he scored on a two-out triple by Erick Aybar.

Morales scored the Angels' sixth run on a fielder's choice grounder by Wells in the third, and Trout made it 7-0 in the fourth with his 22nd homer. The rookie sensation leads the AL with a .340 average and the major leagues with 93 runs scored. He increased his franchise-record stolen base streak to 29 - the most by a rookie since Jimmy Rollins' 35 straight in 2001 with Philadelphia.

Plate umpire Greg Gibson was forced from the game in the bottom of the fifth when Torii Hunter of the Angels slid headfirst in an attempt to score on a double to right field by Kendrys Morales. Hunter tried to get a piece of the plate with his hand as he was tagged by Carlos Santana, but his left spike caught Gibson flush on the left temple and knocked him flat.

Gibson didn't move for a few anxious moments before getting up and leaving the field under his own power after being examined by Angels trainer Rick Smith. He was replaced behind the plate by first base ump Manny Gonzalez. Gibson received several stitches and was taken to a hospital for precautionary X-rays.

NOTES: Hernandez is 0-4 in eight career starts against the Angels. He yielded just nine earned runs over 45 2-3 innings in his other starts against them, and had a loss and two no-decisions against the Angels last season despite giving up just two runs in 20 2-3 innings. His mound opponent in all three games was Dan Haren. ... The Tampa Bay Rays, who lost at Seattle on Wednesday on a perfect game by Felix Hernandez, are back in Anaheim on Thursday night to begin their second series at the "Big A" in three weeks. David Price takes the ball against Haren, who will be looking to extend a string of 30 consecutive outs by the Rays. ... Cleveland's Jason Kipnis opened the game with a single and was thrown out at second by Iannetta on a pitchout. It was the fifth time he has been caught stealing in 28 attempts. ... Hernandez changed his name, but not his uniform number. It's still 55.