Published: Apr 28, 2012 5:25 AM EDT
Updated: Apr 28, 2012 6:31 AM EDT

CHICAGO (AP) - Too many bad pitches left John Danks helpless to stop the White Sox's slide.

Darnell McDonald hit a tiebreaking three-run double and homered to help the Boston Red Sox rally to beat Chicago 10-3 on Friday night and send the White Sox to their fourth straight loss.

David Ortiz hit a two-run shot for the Red Sox, who are 5-0 since blowing a 9-0 lead against the New York Yankees Saturday. Following a five-game losing streak, Boston has won five in a row.

After Paul Konerko's 401st career home run in the fifth gave the White Sox a 3-2 lead, the Red Sox responded with a five-run sixth inning, highlighted by McDonald's bases-clearing double.

"They hit mistakes," said White Sox starter John Danks. "That's plain and simple. I was trying to make pitches, didn't, and they hit them. That's the story of the game."

Boston starter Daniel Bard (2-2) took advantage of the run support and threw seven strong innings. He allowed three runs, two earned, on six hits and retired 13 of the last 14 batters he faced. He struck out six and walked one.

Danks (2-3) struggled in his fifth start of the season. He allowed seven runs on six hits in 5 2-3 innings and walked four. His ERA jumped to 6.23.

"I was ahead in the count and I was trying to bury pitches and wasn't able to do it," Danks said of his command. "There were other times when I couldn't get the ball over the plate."

Danks was unable to hold a 3-2 lead for Chicago in the sixth inning.

He issued back-to-back walks to Adrian Gonzalez and Kevin Youkilis to start the frame. Ortiz then loaded the bases with a single and Cody Ross followed with an RBI single to tie the game. With two outs and the bases still loaded, McDonald lined a double down the left-field line.

"I just simplified things," McDonald said. "Just go up there, try to see the ball and hit the ball."

Marlon Byrd ended Danks' night with an RBI single to put the Red Sox ahead 7-3.

The game was played in cold and windy conditions. The temperature at first pitch was 39 degrees, but it didn't slow the Red Sox hitters. They have hit 12 homers and scored 53 runs over the last six games.

"It's the best (offense) we've seen," White Sox manager Robin Ventura said. "You look up and down that lineup, the way they work counts in the middle part there. John walks the first two guys (in the sixth inning) and that's the stuff that happens with good lineups like that."

Trailing 1-0 in the second inning, Youkilis drew a leadoff walk. Ortiz followed with a two-run shot to right. It was Ortiz's fourth home run of the season and the 382nd of his career. He is tied with former Red Sox great Jim Rice and Frank Howard for 59th on the career list.

Alejandro De Aza led off the first inning with a double down the left-field line. Two outs later, A.J. Pierzynski doubled off the left-field wall to score De Aza.

In the third inning, Alexei Ramirez reached on a Youkilis throwing error and advanced to second on Konerko's bloop single. With two outs, Ramirez came across to score on a passed ball by catcher Kelly Shoppach.

Konerko had two of Chicago's six hits.

Right-hander Dylan Axelrod pitched the final 2 2-3 and allowed one run for the White Sox after getting called up from Triple-A Charlotte Friday afternoon.

Ross and Shoppach had back-to-back RBI singles in the seventh inning to extend the Boston lead to 9-3.

McDonald homered in the ninth.

NOTES: Before the game, a moment of silence was observed for Moose Skowron. Skowron, a five-time World Series champion, died Friday of congestive heart failure at Northwest Community Hospital in Arlington Heights, Ill. He was 81. Skowron helped the New York Yankees win four titles in the 1950s and 1960s. Skowron grew up on Chicago's North Side and he played three seasons (1964-67) with the White Sox. ... White Sox placed reliever Jesse Crain on the 15-day disabled list because of a strained left oblique and recalled Axelrod from Triple-A Charlotte. ... The Red Sox activated left-hander Rich Hill from the 15-day disabled list and optioned reliever Justin Thompson to Triple-A Pawtucket. Hill underwent Tommy John surgery last season.