Published: Apr 27, 2012 4:31 AM EDT
Updated: Apr 27, 2012 6:31 AM EDT

CHICAGO (AP) - Kevin Youkilis hit a grand slam, Jarrod Saltalamacchia homered twice and the Boston Red Sox roughed up Philip Humber in a 10-3 victory over the Chicago White Sox on Thursday night.

Youkilis, mired in an early-season slump, hit his second career slam into the right-field bullpen during a five-run third inning against Humber, who was making his first start since pitching a perfect game in a 4-0 victory at Seattle on Saturday.

There was no such suspense Thursday. Humber walked leadoff batter Mike Aviles in the first, snapping his streak of 29 straight batters retired.

One out later, the right-hander allowed a single to Dustin Pedroia, a dribbler up the third-base line that was the first hit off Humber since Nick Markakis' one-out double for Baltimore in the fifth inning of the Orioles' 10-4 victory at Chicago on April 16.