One person was killed in a two-vehicle crash at Palm Beach Blvd. and Hickey Creek Rd. in Alva at 9:30 pm on Saturday.
Westbound lanes of Palm Beach Blvd. were closed but are now back open.
Drivers should avoid the area if possible while detectives complete their investigation.
Lee county deputies say the driver of a Ford truck pulled out from Hickory Creek Road and was heading westbound on Palm Beach Blvd. when the driver of a Dodge Neon, without its lights on, rear-ended the truck.
The driver of the Neon died on the scene.
They have not released the person's identity.