A vehicle rollover caused the northbound lanes of Alligator Alley to temporarily shut down Wednesday evening.
26-year-old Kyle McGrath of Cape Coral was in serious condition at Naples Community Hospital and 25-year-old Robert Ward of Fort Myers was in critical condition at Lee Memorial Hospital.
According to the Florida Highway Patrol, McGrath was driving northbound on I-75 near mile marker 89 in Collier County when the vehicle entered the median.
McGrath overcorrected causing the vehicle to overturn four times.
Troopers said neither man was wearing a seat belt.
It is unclear if alcohol was related to the crash.